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实验选取健康SD大鼠作为研究对象，研究了丹皮酚对大鼠空肠运动功能的影响.大鼠麻醉后取出大约2 cm长的空肠组织，采用Krebs液进行离体组织灌流保持其生理活性.在灌流液中加入不同剂量的丹皮酚溶液，观察丹皮酚对肠段自发收缩运动的作用，加入乙酰胆碱诱发空肠高张力收缩，而后再加丹皮酚，观察丹皮酚对乙酰胆碱诱发性收缩的作用.研究结果显示丹皮酚对大鼠空肠的自发性收缩与诱发性收缩皆有舒张作用.
Abstract：A Healthy SD rat is selected as the research object to study the effect of paeonol on the jejunal motility function. Approximately 2cm of jejunal tissue is extracted from the anesthetized rat and perfused with Krebs solution to maintain its physiological activity. In the perfusion fluid, different doses of paeonol solution are added, and the effect of paeonol on spontaneous contraction of intestinal segments is observed. Then, acetylcholine is added into the perfusion fluid to induce high tension contraction of the jejunum. After that, the experiment adds paeonol and observes its effect on acetylcholine induced contractions. The results show that paeonol has a relaxing effect on both spontaneous and induced contractions of the rat jejunum.
[1]汤继辉，胡容峰，常宫.丹皮酚大鼠在体小肠吸收动力学研究[J].中国实验方剂学杂志，2006(7):35-37.
[2]汪宝琪，庞志功，张清.牡丹皮徐长卿中丹皮酚吸收代谢的对比研究[J].西安医科大学学报(中文版),1995(1):47-48+55.
[3]吴桂莹，亓玉玲，郝宝燕，等.丹皮酚衍生物及其药理活性研究进展[J].中草药，2019,50(4):1001-1006.
[4]武氏芳，刘琼云，史雯星，等.丹皮酚与丹皮酚微囊在大鼠小肠吸收的比较研究[J].海峡药学，2016,28(4):16-18.
[5]祁建宏，董芳旭.丹皮酚现代药理作用及其机制研究进展[J].北京联合大学学报，2023,37(2):72-78.
[6]Huang L,Zhang B,Yang Y,et al.Synthesis and Anti-inflammatory Activity of Paeonol Analogues in the Murine Model of Complete Freund’s Adjuvant Induced Arthritis[J].Bioorganic Medicinal Chemistry Letters,2016,26(21):5218-5221.
[7]胡容峰，方成武，邹爱峰，等.丹皮酚与丹皮酚-β环糊精包合物大鼠在体小肠吸收动力学对照[J].中国中药杂志，2008(1):35-37.
[8]张微，李凌军，王瑛兰.天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收动力学[J].中国实验方剂学杂志，2012,18(4):150-153.
[9]张毅，薛美玲，王会盈，等.丹皮酚分析检测的研究进展[J].化工与医药工程，2024,45(2):60-64.
[10]Meng Z,Xueqian X,Bo X,et al.Paeonol Alleviates Ulcerative Colitis in Mice by Increasing Short-chain Fatty Acids Derived from Clostridium Butyricum[J].Phytomedicine,2023,1(20):155056-155059.
[11]Long L,Xing Li S,Tian Tian B,et al.New Paeonol Derivative C302 Reduces Hypertension in Spontaneously Hypertensive Rats Through Endothelium-dependent and Endothelium-independent Vasodilation[J].European journal of pharmacology,2022,9(27):175057-175060.
[12]张金艳，余学钊，赵乐，等.丹皮酚对高血脂模型大鼠肠系膜上动脉的舒张作用[J].中药新药与临床药理，2013,24(5):484-486.
[13]Jin X,Wang J,Xia Z M,et al.Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking Mapk/erk/p38 Signaling Pathway [J].Inflammation,2016,39(1):434-446.
[14]Hafez H M,Morsy M A,Mohamed M Z,et al.Mechanisms Underlying Gastroprotective Effect of Paeonol Against Indomethacin-induced Ulcer in Rats [J].Hum Exp Toxicol,2019,38(5):510-518.
[15]陈茜，骆建宇，邝枣园，等.丹皮酚对大脑中动脉缺血模型小鼠行为功能障碍的改善作用研究[J].中国全科医学，2023,26(27):3441-3449.
基本信息:
DOI：10.16393/j.cnki.37-1436/z.2024.05.018
中图分类号:R285.5
引用信息:
[1]路雯,刘维豪,胡晨晨,等.丹皮酚对大鼠空肠运动的影响[J].菏泽学院学报,2024,46(05):123-128.DOI:10.16393/j.cnki.37-1436/z.2024.05.018.
基金信息:
国家自然科学基金(82200477); 菏泽学院博士科研基金项目(XY22BS21)
2024-10-15
2024-10-15