王鹏

• 1:安徽警官职业学院警体技能训练部

摘要(Abstract)：

在过去的30年中,久坐不动的生活方式和过量的食物供应相结合,导致肥胖的患病率和代谢综合征及2型糖尿病的发病率显著增加.已有研究表明,体力活动水平低,每日能量消耗减少,导致内脏脂肪堆积,因此,氧化应激/炎症级联反应的激活是胰岛素抵抗型糖尿病发展和微血管并发症发生的基础.着重探讨了氧化应激和炎症参与2型糖尿病发病的病理生理途径,以及规律运动(训练)作为一种天然抗氧化剂和抗炎策略对预防2型糖尿病及其严重并发症的影响.

关键词(KeyWords)： 体育运动;规律;2型糖尿病;抗氧化;抗炎;机制

Abstract:

Keywords:

基金项目(Foundation): 安徽省高等学校自然科学重点项目(KJ2018A0462)

作者(Author): 王鹏

DOI: 10.16393/j.cnki.37-1436/z.2018.05.015

参考文献(References)：

• [1]Lamb R E,Goldstein B J.Modulating an oxidative-inflammatory cascade:potential new treatment strategy for improving glucose metabolism,insulin resistance,and vascular function[J].International Journal of Clinical Practice,2008,62(7):1087-1095.
• [2]Gupta S,Chough E,Daley J,et al.Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATpase activity[J].American Journal of Physiology,2002,282(3):C560-C566.
• [3]Droge W.Free radicals in the physiological control of cell function[J].Physiological Reviews,2002,82(1):47-95.
• [4]Lee H C,Wei Y H.Oxidative stress,mitochondrial DNA mutation,and apoptosis in aging[J].Experimental Biology and Medicine,2007,232(5):592-606.
• [5]Pickup J C.Inflammation and activated innate immunity in the pathogenesis of type 2 diabletes[J].Diabetes Care,2004,27(3):813-823.
• [6]Jankord R,Jemiolo B.Influence of physical activity on serum IL-6and IL-10levels in healthy older men[J].Medicine and Science in Sports and Exercise,2004,36(6):960-964.
• [7]Huang W,Glass C K.Nuclear receptors and inflammation control:molecular mechanisms and pathophysiological relevance[J]. Arteriosclerosis,Thrombosis,and Vascular Biology,2010,30(8):1542-1549.
• [8]Evans J L,Goldfine I D,Maddux B A,et al.Oxidative stress and stress-activated signaling pathways:a unifying hypothesis of type 2diabetes[J].Endocrine Reviews,2002,23(5):599-622.
• [9]Lindstr9m J,Ilanne-Parikka P,Peltonen M,et al.Sustained reduction in the incidence of type 2diabetes by lifestyle intervention:follow-up of the Finnish Diabetes Prevention Study[J].The Lancet,2006,368(9548):1673-1679.
• [10]Finaud J,Lac G,Filaire E.Oxidative stress:relationship with exercise and training[J].Sports Medicine,2006,36(4):327-358.
• [11]Gleeson M.Immune function in sport and exercise[J].Journal of Applied Physiology,2007,103(2):693-699.
• [12]Stewart L K,Flynn M G,Campbell W W,et al.The influence of exercise training on inflammatory cytokines and C-reactive protein[J]. Medicine and Science in Sports and Exercise,2007,39(10):1714-1719.
• [13]Ceriello A,Quagliaro L D,Amico M,et al.Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat[J].Diabetes,2002,51(4):1076-1082.
• [14]Giacco F,Brownlee M.Oxidative stress and diabetic complications[J].Circulation Research,2010,107(9):1058-1070.
• [15]Mantel C,Messina-Graham S V,Broxmeyer H E.Superoxide flashes,reactive oxygen species,and the mitochondrial permeability transition pore:potential implications for hematopoietic stem cell function[J].Current Opinion in Hematology,2011,18(4):208-213.
• [16]Shanmugam N,Gonzalo I T G,Natarajan R.Molecular mechanisms of high glucose-induced cyclooxygenase-2expression in monocytes[J].Diabetes,2004,53(3):795-802.
• [17]Caro A A,Cederbaum A I.Oxidative stress,toxicology,and pharmacology of CYP2E1[J].Annual Review of Pharmacology and Toxicology,2004,44:27-42.
• [18]Wang Z,Hall S D,Maya J F,et al.Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1in humans[J].British Journal of Clinical Pharmacology,2003,55(1):77-85.
• [19]Rector R S,Warner S O,Liu Y,et al.Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome[J].American Journal of Physiology,2007,293(2):E500-E506.
• [20]Vincent H K,Bourguignon C,Vincent K R.Resistance training lowers exercise-induced oxidative stress and homocysteine levels in overweight and obese older adults[J].Obesity,2006,14(11):1921-1930.
• [21]Oliveira V N,Bessa A,Jorge M L,et al.The effect of different training programs on antioxidant status,oxidative stress,and metabolic control in type 2diabetes[J].Applied Physiology,Nutrition,and Metabolism,2012,37(2):334-344.