贾玉梅,刘洪涛,曹希传

• 1:中国矿业大学化工学院
• 2:中国矿业大学材料学院

摘要(Abstract)：

在人工关节摩擦磨损试验中,采用体积分数为25%的小牛血清去离子水稀释液为润滑液,以钴铬钼合金及超高相对分子质量聚乙烯(UHMWPE)颗粒为摩擦副.探讨了外加40kHz超声频率时,在不同超声功率和不同超声作用时间下,牛血清蛋白降解效果及模拟润滑液中UHMWPE颗粒的聚集情况.结果表明:蛋白浓度随超声作用时间降低,随超声功率升高降低,说明超声破碎对高分子蛋白具有一定的降解作用;超声对牛血清UHMWPE悬浮液中颗粒具有凝聚作用,聚集体的含量随着超声处理时间的延长而增多,聚集体体积随着超声处理时间的延长而减小.

关键词(KeyWords)： 超声辅助法;提取;超高相对分子质量聚乙烯;关节磨屑;人工关节

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(51075387);; 国家卫生部基金资助项目(LW201004)

作者(Author): 贾玉梅,刘洪涛,曹希传

DOI: 10.16393/j.cnki.37-1436/z.2013.02.015

参考文献(References)：

• [1]Margevicius K J,Bauer T W,McMahon J T,et al.Isola-tion and characterization of debris in membranes around totaljoint prostheses[J].Bone Joint Surg.,1994,76-A:1664–1675.
• [2]Widding M,Scott K,Jani S.Do current wear particle isola-tion procedures underestimate the number of particles gener-ated by prosthetic bearing components?[J].Wear,2001,25:1213–1217.
• [3]Tipper J L,Ingham E,Hailey J L,et al.Quantitative a-nalysis of polyethylene wear debris,wear rate and headdamage in retrieved Charnley hip prostheses[J].Mater.Sci.:Mater.Med,1999,11:117–124.
• [4]Shanbhag A S,Jacobs J J,Glant T T,et al.Compositionand morphology of wear debris in failed uncemented total hipreplacement[J].Bone Joint Surg.,1994,76-B:.60–67.
• [5]Campbell P,Ma S,Yeom,B,et al.Isolation of predomi-nantly sub-micron sized UHMWPE wear particles fromperiprosthetic tissues[J].Biomed.Mater.Res.,1995,29:127–131.
• [6]Bell J,Tipper J L,Ingham E,et al.Quantitative analysisof UHMWPE wear debris isolated from the periprostheticfemoral tissues from a series of Charnley total hip arthoplas-ties[J].Biomed.Mater.Eng.,2002,12:198-201.
• [7]Mabrey J D,Afsar-Keshmiri A,Sychterz C J,et al.Standardized analysis of UHMWPE wear particles fromfailed total joint arthoplasties[J].Biomed.Mater.Res.(Appl.Biomater.),2002,63:475–483.
• [8]Maloney W J,Smith R L,Schmalzried T P,et al.Isolationand characterization of wear particles generated in patientswho have had failure of a hip arthroplasty without cement[J].Bone Joint Surg.,1995,77-A:1301–1310.
• [9]罗昭锋,瞿鑫,沐万孟,等.超声和高压处理对牛血清白蛋白结构的影响[J].中国生物工程杂志,2006,26(1):46–49.