冯凤鹃,曲志才,田李,王转斌

• 1:曲阜师范大学生命科学学院

摘要(Abstract)：

1987年,由Selker等在粗糙脉孢菌中首次发现重复序列诱导点突变(repeat-induced point mutation,RIP).在重复序列诱导点突变过程中,搜寻前减数分裂组织单倍体核中DNA的重复序列,然后发生众多的碱基C到T的突变,产生富碱基T+A片段,从而使重复序列中的G-C碱基对发生转换突变成为A-T碱基对.此外,发生RIP的序列多集中在着丝粒区域,主要是转座子甲基化后的遗迹.移动转座子是真核生物基因组进化的主要驱动力.对于真菌,重复序列诱导点突变(RIP)在减数分裂过程中通过突变多拷贝DNA,能最大限度地减少转座子的影响,因此对RIP的研究在一定程度上能有助于了解基因组进化的真谛.综述了重复序列诱导点突变的产生机制,以及真菌中重复序列诱导点突变的研究进展.

关键词(KeyWords)： 真菌;DNA序列;重复序列诱导点突变;研究进展

Abstract:

Keywords:

基金项目(Foundation): 中国博士后科学基金资助项目(2013M531567);; 山东省自然科学基金资助项目(ZR2013CQ018)

作者(Author): 冯凤鹃,曲志才,田李,王转斌

DOI: 10.16393/j.cnki.37-1436/z.2014.05.009

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