一种常温下有效的芳基酮α-溴代方法A Mild and Efficient Procedure for α-Bromination of Aryl Ketone
邹娜,刘晓慧
摘要(Abstract):
在乙酸铵(NH4OAc)催化下,芳香酮和N-溴代丁二酰亚胺(NBS)反应合成了6种α-溴代芳基酮,产率为65%~79%.最佳反应条件为:常温,乙醚为溶剂,n(芳基酮)∶n(NBS)∶n(NH4OAc)=1∶1.3∶0.5,反应时间1.5~2 h.该反应条件温和,反应时间较短,操作简便,产率较高.
关键词(KeyWords): 芳基酮;N-溴代丁二酰亚胺;乙酸铵;α-溴代芳基酮
基金项目(Foundation):
作者(Author): 邹娜,刘晓慧
DOI: 10.16393/j.cnki.37-1436/z.2014.05.010
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